Table 1.
Literature reports of CNS infections caused by Mycoplasma hominis in non-neonatal patients (1950-2016.7)
| No. | Author & year | Pt age(years), sex | Pt Country | HU | Tr | SI | Clinical manifestation | Days to Dx after Ad | Dx basis | Antibiotics used prior to diagnosis | Final antibiotic regimen | Otc | Ref |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Paine et al. [14] | 20, M | USA | N | Y | Y | fever, headache, a stiff neck | 18 | C | S + P + St | Sm | CR | [14] |
| 2 | Payan et al. [15] | 29, M | USA | Y | Y | Y | fever, loss of consciousness | 23 | C | O + Cp + N + C | T + E | CR | [15] |
| 3 | Madoff S et al. [16] | 11, F | USA | N | N | Y | fever | 26 | GIT + IRT | V + E | Mc | De | [16] |
| 4 | McMahon et al. [24] | 76, M | USA | N | N | Y | fever, unresponsive | 18 | C | P + G | none | De | [24] |
| 5 | Kersten RC et al. [17] | 20, M | USA | Y | Y | Y | fever, comatose | 19 | C | A + M + Su + V + Cf | M + Cf + Az + Am + Cl | Re | [17] |
| NM | 35 | C | Az + Am + Cl | M + Cf + D + Cd | CR | [17] | |||||||
| 6 | Cohen & Kubak. [25] | 18, F | USA | N | Y | Y | fever, altered mental status | 20 | C | E | D + Ci + C | CR | [25] |
| 7 | Zheng et al. [18] | 22, F | USA | N | N | Y | fever, left-sided weakness and numbness | 18 | IRT + IBA | Ct + N + Ca + M | none | CR | [19] |
| 8 | Douglas et al. [19] | 17, F | Australia | N | Y | Y | fever, headache, photophobia, nausea, vomiting | 13 | C + 16S | A + Ca + E | D + Cd | CR | [19] |
| 9 | House P et al. [20] | 40, F | Spain | N | N | Y | headache, left facial weakness, nausea, afebrile | 12 + “several” | C + 16S | V + Cf + M | Ci + M | CR | [20] |
| 10 | Kupila L et al. [21] | 40, M | Finland | N | Y | Y | haematuria and urine retention, confused | 14 | 16S | none | T | CR | [21] |
| 11 | McCarthy & Looke. [3] | 48, M | Australia | N | N | Y | fever | 36 | C + 16S | Cz + V | Ga + Cd | CR | [3] |
| 12 | McCarthy & Looke. [3] | 17, F | Australia | N | Y | Y | fever | 17 | C | V + Me | Ga + Mo | CR | [3] |
| 13 | Al Masalma et al. [22] | 41, F | Russia | N | N | Y | vertigo, coma headache, hemiparesis | 10 | 16S | V + Me | D | CR | [22] |
| 14 | Lee et al. [8] | 48, F | Netherlands | Y | Y | Y | fever | 15 | 16S | F + V | Mo | CR | [8] |
| 15 | Henao-Martínez et al. [10] | 40, M | Somalia | N | Y | Y | fever | 17 | C + 16S | V + PT + Ct + M | D | CR | [10] |
| 16 | Pailhorie ‘s et al. [23] | 43, M | France | N | Y | Y | fever, delirium tremens | 13 | Vitek MS + 16S | Me + V + Fo | L + D | CR | [23] |
| 17 | Whitson WJ [2] | 17, M | USA | Y | Y | Y | fever, bicep and deltoid weakness | 32 | C | PT + V + Ct + M | D + Mo | CR | [2] |
| 18 | Hos NJ [27] | 21, F | Germany | N | N | Y | fever, neck pain, nausea, vomiting, | 31 | C + 16S | A + Ct | Mo | CR | [27] |
| 19 | Reissier S [26] | 39, M | France | N | Y | Y | afbrile, loss of consciousness | 33 | C + 16S + RT-PCR | PT + Li + Ct + Me + V | Mo | De | [26] |
| 20 | Present study | 79, M | China | N | N | Y | fever, anepia and right-sided weakness | 17 | 16S | Me + V + CF | Az + D + Mi | CR |
Ad admitted, C culture, CR clinical recovery, De death, Dx diagnosis, GIT growth inhibition test, HU hormone use, IBA immunoblot assay, IRT immunofluo-rescence test, Otc outcome, Re recurrence, Ref reference, SI surgical intervention, 16S 16S rDNA sequencing, RT-PCR real-time PCR, Tr trauma, yrs: years
Ampicillin, (A) amoxicillin, (Am) azithromycin, (Az) chloramphenicol, (C) cefazolin, (Ca) clindamycin, (Cd) cefotaxime, (Cf) ciprofloxacin, (Ci) clavulanate potassium, (Cl) cephalothin (Cp), ceftriaxone (Ct), ceftazidime (Cz), cefoperazone/ sulbactam (CF), doxycycline (D), erythromycin (E),flucloxacillin (F), fosfomycin (Fo),gentamicin (G), gatifloxacin (Ga),levofloxacin (L), linezolid (Li), metronidazole (M), methacycline (Mc), meropenem (Me), minocyline (Mi), moxifloxacin (Mo),nafcillin (N), oxacillin (O),penicillin (P), piperacillin/tazobactam (PT), sulfadiazine (S), streptomycin (Sm), sulfathiazole (St), sulbactam (Su), tetracycline (T), vancomycin (V)