Table 3.

Intersect of significantly increased IgG autoantibodies in patients with RA (cohorts A, B, and C)

Antigen			Cohort A			Cohort B			Cohort C
symbol	Name	Gene ID	P	FC	S	P	FC	S	P	FC	S
GNPTG	N-acetylglucosamine-1-phosphate transferase	84572	0.021	1.2	17	0.001	1.3	13	0.04	1.1	10
HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1-like 2	144983	0.020	1.3	22	0.000	1.3	34	0.001	1.1	24
IGFBP2	Insulin-like growth factor binding protein 2	3485	0.01	1.2	19	0.000	1.5	13	0.03	1.1	15

Cohort A: patients with established rheumatoid arthritis (RA) (n = 72). cohort B: early RA (n = 116). cohort C: early seronegative RA (n = 184). P is p value for fold change (FC) and sensitivity (S) at 90 % specificity compared to matched healthy controls, according to the Mann-Whitney test