Table 4.
IC50 value of isolated compounds against A549 cell lines at 48 and 72 h incubation and MRC5 cell line at 72 h treatment
| Isolated Compounds | IC50 in μg/ml (μM) | ||
|---|---|---|---|
| (A549) | (MRC5) | ||
| 48 h | 72 h | 72 h | |
| Graveoline | 76.3 ± 2.08 (273.5) | 44.6 ± 0.47 (159.9) | 69.7 ± 2.5 (249.8) |
| Kokusaginine | 87.4 ± 7.08 (337.5) | >100 (>386.1) | 74.8 ± 0.82 (288.8) |
| Bergapten | >100 (>463.0) | 43.53 ± 1.81 (201.5) | >100 (>463.0) |
| Moskachan B | >100 (>454.5) | >100 (>454.5) | >100 (>454.5) |
| Moskachan D | 77.5 ± 3.0 (312.5) | 18.5 ± 0.65 (74.6) | 90.8 ± 0.8 (366.1) |
| Chalepensin | 30.5 ± 1.30 (120.1) | 14.0 ± 0.15 (55.1) | 23.3 ± 0.55 (91.7) |
| Rutamarin | 56.3 ± 1.53 (158.1) | 68.5 ± 3.06 (192.4) | >100 (>281.0) |
| Arborinine | 27.7 ± 0.26 (97.2) | 13.1 ± 0.06 (46.0) | 20.8 ± 0.15 (73.0) |
| Chalepin | 28.3 ± 1.06 (90.1) | 8.69 ± 2.43 (28.0) | 23.4 ± 0.6 (74.5) |
| Neophytadiene | 69.2 ± 1.06 (248.9) | 68.00 ± 2.43 (244.6) | 77.4 ± 0.98 (278.4) |
| Cisplatina | - | 24.5 ± 1.8 (81.67) | >100 (>333.33) |
aCisplatin was used as the positive standard reference. Tabulated values are mean ± standard deviation (SD) of three replicates