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. Author manuscript; available in PMC: 2016 Oct 12.
Published in final edited form as: Atherosclerosis. 2016 Jul 29;252:128–135. doi: 10.1016/j.atherosclerosis.2016.07.927

Fig. 5. LDL mRNA expression in VSMCs stimulated with UTP. VSMCs from P2Y2R−/− mice were transiently transfected with cDNA encoding a hemagglutinin-tagged WT P2Y2R or a mutant P2Y2R that does not bind FLN-A.

Fig. 5

Untransfected VSMCs showed the highest LDLR mRNA relative abundance compared to both transfected groups, although LDLR mRNA abundance was not significantly different between untransfected and WT P2Y2R−/−transfected VSMCs. Additionally, VSMCs expressing the mutant P2Y2R exhibited significantly lower LDLR mRNA relative abundance than VSMCs transfected with the WT P2Y2R. Same letters represent no significant difference between the groups. Different letters represent significant differences between groups (p < 0.05). GAPDH was used as a control gene.