(a) Mass of tumors derived from control or β2AR-deficient cells, from mice exposed to non-stress or stress conditions (n = 5). (b – d) Pearson correlation analysis of the relationship between the effect of stress on the trajectory of metastasis and the effect of stress on the trajectory of primary tumor growth in mice bearing (b) control (r2 = 0.001938, p = 0.944), (c) shADRB2a (r2 = 0.9224, p = 0.0094), and (d) shADRB2b (r2 = 0.6995, p = 0.0775) tumors. #p < 0.05 for main stress effect by two-way ANOVA.