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. 2015 Nov 2;16(3):1021–1030. doi: 10.1111/ajt.13487

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© 2015 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of American Society of Transplant Surgeons

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Follow‐up of patient 1. Biochemical follow‐up before and after hepatocyte transplantation. (A) Total serum bilirubin (●) and conjugated serum bilirubin (▴). (B) ALT. (C) CRP. Arrows indicate time points of first and second hepatocyte transplantation, scabies manifestation, presumed rejection, and liver transplantation. (D) Development of de novo PRA to class I and II HLA antigens. HLA class I antibodies to A1, A2, A3, A11, A25, A26, A29, A30, A31, A 32, A33, A34, A36, A43, A66, A68, A69, A74, A80, B8, B44, B45, B59, B76, and B82 and class II antibodies to DR4, DR12, DR53, DQ2, DQ4, DQ8, DQ9, and HLACw7 could be detected. HLA A1, A2, A11, B8, B44, DR4, DR12, and DQ2 were donor‐specific antibodies. (E) Tacrolimus whole‐blood concentrations. ALT, alanine aminotransferase; CRP, C‐reactive protein; D/C, immunosuppression discontinued; LTX, liver transplantation; PRA, panel reactive antibodies; Tx, transplant.