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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Jul 28;36(9):1900–1909. doi: 10.1161/ATVBAHA.116.307869

Figure 3. Effect of inhibition of NADPH oxidase and TGF-β signaling on Vascular reactivity in STIM1 and CHOP knockout mice.

Figure 3

Wire Myograph vascular reactivity showing endothelial-dependent relaxation in response to acetylcholine before and after incubation with TGF-β inhibitors (SB431542) and NADPH oxidase inhibitor (gp91 ds-tat) in mesenteric resistance arteries from: - WT mice infused with saline or Ang II (A, B, n=5) - Heterozygous Stim1 knockout specifically in SMC (Stim1SMC−/+) mice infused with saline or Ang II (C, D, n=5) - Homozygous Stim1 knockout specifically in SMC (Stim1SMC−/−) mice infused with saline or Ang II (E, F, n=5) - CHOP knockout (CHOP−/−) mice infused with saline or Ang II (G, H, n=5) Two-way repeated measured ANOVA followed by Tukey's Post-Hoc test were applied for figures (A, B, C, D, E, F, G H). *p<0.05 between WT + Ang II + gp91 ds-tat vs WT + Ang II, WT + Ang II + SB. ^p<0.05 between WT, STIMSMC−/+ + Ang II + gp91 ds-tat vs STIMSMC−/+ + Ang II, STIMSMC−/+ + Ang II + SB. $p<0.05 between WT vs. STIMSMC−/− + Ang II + gp91 ds-tat, STIMSMC−/− + Ang II, STIMSMC−/− + Ang II + SB.