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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Jul 28;36(9):1900–1909. doi: 10.1161/ATVBAHA.116.307869

Figure 4. Effect of tunicamycin-induced ER stress on vascular reactivity in STIM1 knockout mice.

Figure 4

Body weight (A, n=5) and systolic blood pressure measured by tail cuff machine (B, n=5), Wire Myograph vascular reactivity showing endothelial-dependent relaxation in response to acetylcholine (C, n=5) and eNOS levels determined by an ELISA Kit (D, n=3) in MRA from WT, heterozygous (Stim1SMC−/+) and homozygous Stim1 knockout specifically in SMC (Stim1SMC−/−) mice treated with saline or Tunicamycin. Two-way repeated measured ANOVA followed by Tukey's Post-Hoc test were applied for figures (A, B, C). One-way ANOVA followed by Bonferroni Post-Hoc test were applied for figures (D). $p<0.05 between STIMSMC−/+ + Tunica vs. WT, STIMSMC−/−, STIMSMC−/+. *p<0.05 between STIMSMC−/+ + Tunica, WT + Tunica vs. WT, STIMSMC−/−, STIMSMC−/+. &p<0.05 between STIMSMC−/− vs. STIMSMC−/− + Tunica. ^p<0.05 between STIMSMC−/−, STIMSMC−/− + Tunica vs. STIMSMC−/+ + Tunica, WT + Tunica. %p<0.05 between STIMSMC−/− + Tunica vs. STIMSMC−/+ + Tunica and WT + Tunica.