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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Jul 28;36(9):1900–1909. doi: 10.1161/ATVBAHA.116.307869

Figure 5. Effect of inhibition of NADPH oxidase and TGF-β signaling on Vascular reactivity in tunicamycin-treated STIM1 knockout mice.

Figure 5

Wire Myograph vascular reactivity showing endothelial-dependent relaxation in response to acetylcholine before and after incubation with TGF-β inhibitor (SB431542) and NADPH oxidase inhibitor (gp91 ds-tat) in mesenteric resistance arteries from: - WT mice treated with saline or Tunicamycin (A, n=5) - Heterozygous Stim1 knockout specifically in SMC (Stim1SMC−/+) mice treated with saline or Tunicamycin (B, n=5) - Homozygous Stim1 knockout specifically in SMC (Stim1SMC−/−) mice treated with saline or Tunicamycin (C, n=5) Two-way repeated measured ANOVA followed by Tukey's Post-Hoc test were applied for figures (A, B, C). *p<0.05 between WT, WT + Tunica + gp91 ds-tat vs Sham + Tunica, WT + Tunica + SB. $p<0.05 between STIMSMC−/+ vs STIMSMC−/+ + Tunica + gp91 ds-tat. @p<0.05 between STIMSMC−/+ + Tunica + gp91 ds-tat vs STIMSMC−/+ + Tunica, STIMSMC−/+ + Tunica + SB. $p<0.05 between STIMSMC−/− vs STIMSMC−/− + Tunica, STIMSMC−/− + Tunica + gp91 ds-tat, STIMSMC−/− + Ang II, STIMSMC−/− + Tunica + SB.