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. Author manuscript; available in PMC: 2017 Feb 10.
Published in final edited form as: J Control Release. 2016 Jun 4;235:306–318. doi: 10.1016/j.jconrel.2016.06.004

Fig. 3.

Fig. 3

Comparison of pharmacokinetic profiles and tumor-uptake of dual-labeled 1st generation conjugate 111In-P-EPI-125I and 2nd generation conjugate 111In-2P-EPI-125I in nu/nu mice. (A) Blood activity-time profiles of 111In-labeled polymer carriers and 125I labeled drug EPI in mice. (B) Radioactivity level in tumors for the mice bearing subcutaneous A2780 xenografts 48 h after intravenous injection of dual radiolabeled conjugates. Here 111In corresponds to polymer carrier (1st generation P- and 2nd generation 2P-) and 125I to drug EPI, respectively. The data represent the mean radioactivity expressed as a percentage of the injected dose per gram of blood (n = 5). p < 0.001.