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Effect of radiolabeling strategy on pharmacokinetic profiles of the polymer carrier (A) and payload (EPI) (B) of backbone degradable diblock HPMA copolymer-EPI conjugates in tumor-bearing nu/nu mice. 2P-DTPA-EPI(Tyr) with average Mw 66 kDa and 2P-Tyr-EPI(DTPA) with Mw 75 kDa were used. Data obtained using the radioactivity count method are plotted as percentage of injected dose per gram of tissue (%ID/g). All data are expressed as mean ± standard deviation (n = 5).
