. Author manuscript; available in PMC: 2017 Feb 10.

Published in final edited form as: J Control Release. 2016 Jun 4;235:306–318. doi: 10.1016/j.jconrel.2016.06.004

Table 4.

Comparison of pharmacokinetic parameters of dual-labeled (¹²⁵I- and ¹¹¹In-based) 1st generation conjugate and 2nd generation conjugates in mice.

	1st generation		2nd generation
Conjugate	¹¹¹In-P-EPI-¹²⁵I		¹¹¹In-2P-EPI-¹²⁵I		¹²⁵I-2P-EPI-¹¹¹In
Component	EPI(Tyr)-¹²⁵I	P(DTPA)¹¹¹In	EPI(Tyr)¹²⁵I	2P(DTPA)¹¹¹In	EPI(DTPA)¹¹¹In	2P(Tyr)¹²⁵I
T_1/2,α (h)	0.57 ± 0.07	0.50 ± 0.08	1.51 ± 0.20	1.58 ± 0.19	0.49 ± 0.13	0.47 ± 0.16
T_1/2,β (h)	9.63 ± 11.47	9.20 ± 1.68	29.79 ± 1.62	31.52 ± 2.01	28.40 ± 2.03	31.11 ± 2.19
AUC (% ID h/mL)	260.72 ± 24.64	324.25 ± 36.98	1135.00 ± 43.81	1473.97 ± 65.83	1604.36 ± 95.44	1628.32 ± 97.28
CL (mL/h)	0.38 ± 0.03	0.30 ± 0.03	0.08 ± 0.003	0.06 ± 0.003	0.06 ± 0.003	0.06 ± 0.004
MRT (h)	13.01 ± 1.96	12.46 ± 2.25	41.85 ± 2.21	43.95 ± 2.73	40.71 ± 2.89	44.69 ± 13.15
Vss (mL)	4.99 ± 0.31	3.84 ± 0.29	3.68 ± 0.08	2.98 ± 0.08	2.53 ± 0.05	2.74 ± 0.06

T_1/2,α = initial half-life; T_1/2,β = terminal half-life; AUC = total area under the blood concentration versus time curve; %ID = percentage of injected dose; CL = total body clearance; MRT = mean residence time; Vss = steady-state volume of distribution. Data are presented as mean ± standard deviation (n = 5).