APMA | N-(3-aminopropyl)methacrylamide hydrochloride |
Boc-GFLG-OMe | methyl9-benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-12-propyl-3-oxa-5,8,11,14-tetraazahexadecan-16-oate |
Boc-GFLG-NH2 | tert-butyl(14-amino-4-benzyl-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazatetradecyl)carbamate |
CTA | chain transfer agent (4-cyanopentanoic acid dithiobenzoate) |
CTA-GFLG-CTA | 10-benzyl-2,25-dicyano-13-isobutyl-5,8,11,14,17,22-hexaoxo-6,9,12,15,18,21-hexaazahexacosane-2,25-diyl dibenzodithioate |
DCC | N,N′-dicyclohexylcarbodiimide |
DMAP | 4-(dimethylamino) pyridine |
EPI | epirubicin |
Fmoc-Abu(N3)-OH | (S)-2-(Fmoc-amino)-4-azidobutanoic acid |
HPMA | N-(2-hydroxypropyl)methacrylamide |
HATU | 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxidhexafluorophosphate |
HOBt | 1-hydroxybenzotriazole |
111In-P-EPI-125I | frist generation HPMA copolymer-EPI conjugate with 111In-DTPA labeled polymer backbone and 125I-Tyr labeled EPI |
111In-2P-EPI-125I | second generation HPMA copolymer-EPI conjugate with 111In-DTPA labeled polymer backbone and 125I-Tyr labeled EPI |
125I-2P-EPI-111In | second generation HPMA copolymer-EPI conjugate with 125I-Tyr labeled polymer backbone and 111In-DTPA labeled EPI |
MA-Tyr-NH2 | N-methacryloyltyrosinamide |
MA-GFLG-OH | N-methacryloylglycylphenylalanylleucylglycine |
MA-GFLG-Abu(N3)-OH |
N-(2-((4-azido-1-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy) tetrahydro-2H-pyran-4-yl)amino)-1-oxobutan-2-yl)amino)-2-oxoethyl)-2-(2-(2-methacrylamidoacetamido)-3-phenylpropanamido)-4-methylpentanamide |
MA-GFLG-Abu(N3)-EPI |
N-(2-((4-azido-1-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl) oxy)tetrahydro-2H-pyran-4-yl)amino)-1-oxobutan-2-yl)amino)-2-oxoethyl)-2-(2-(2-methacrylamidoacetamido)-3-phenylpropanamido)-4-methylpentanamide |
MA-GFLG-Abu(Tyr)-EPI | 2-(4-(1-(12-benzyl-3-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6, 11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)carbamoyl)-9-isobutyl-18-methyl-5, 8,11,14,17-pentaoxo-4,7,10,13,16-pentaazanonadec-18-en-1-yl)-1H-1,2,3-triazol-5-yl)butanamido)-3-(4-hydroxyphenyl)propanoic acid |
MA-GFLG-NHBoc | tert-butyl(11-benzyl-8-isobutyl-17-methyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadec-17-en-1-yl)carbamate |
MA-GG-EPI |
N-(2-((2-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6, 11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)methacrylamide |
NH2-GFLG-NH2 | 2-(2-(2-aminoacetamido)-3-phenylpropanamido)-N-(2-((2-aminoethyl)amino)-2-oxoethyl)-4-methylpentanamide |
p-SCN-Bn-DTPA | 2,2′-((1-((2-((2-carboxyethyl)(carboxymethyl)amino)ethyl)(carboxymethyl)amino)-3-(4-thiocyanatophenyl)propan-2-yl)azanediyl)diacetic acid |
P-EPI | first generation HPMA and MA-GFLG-EPI copolymer conjugate |
P-EPI-Tyr | first generation HPMA and MA-GFLG-Abu(Tyr)-EPI copolymer conjugate |
P-EPI-N3 | first generation HPMA, APMA and MA-GFLG-Abu(N3)-EPI copolymer conjugate |
P-DTPA-EPI(Tyr) | first generation HPMA copolymer-EPI conjugate with DTPA pendent on polymer backbone and tyrosine moiety attachment with EPI |
2P-EPI-N3 | second generation HPMA, APMA and MA-GFLG-Abu(N3)-EPI copolymer conjugate |
2P-DTPA-EPI(Tyr) | second generation HPMA copolymer-EPI conjugate with DTPA pendent on polymer back bone and tyrosine moiety attachment with EPI |
2P-Tyr-EPI-N3 | second generation HPMA, MA-Tyr-NH2 and MA-GFLG-Abu(N3)-EPI copolymer conjugate |
2P-Tyr-EPI(DTPA) | second generation HPMA copolymer-EPI conjugate with tyrosine moiety pendent on polymer backbone and DTPA attachment with EPI |
RAFT | reversible addition-fragmentation chain transfer |
TBTA | tris(benzyltriazolylmethyl)amine |
TFA | trifluoroacetic acid |
Hexynoic-Tyr | 2-(hex-5-ynamido)-3-(4-hydroxyphenyl)propanoic acid |
V-65 | 2,2′-azobis(2,4-dimethylvaleronitrile) |
V-501 | 4,4-azobis (4-cyanopentanoic acid) |
VA-044 | 2,2′-azobis[2-(2-imidazolin-2-yl) propane]dihydrochloride |