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. Author manuscript; available in PMC: 2017 Feb 10.
Published in final edited form as: J Control Release. 2016 Jun 4;235:306–318. doi: 10.1016/j.jconrel.2016.06.004
APMA N-(3-aminopropyl)methacrylamide hydrochloride
Boc-GFLG-OMe methyl9-benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-12-propyl-3-oxa-5,8,11,14-tetraazahexadecan-16-oate
Boc-GFLG-NH2 tert-butyl(14-amino-4-benzyl-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazatetradecyl)carbamate
CTA chain transfer agent (4-cyanopentanoic acid dithiobenzoate)
CTA-GFLG-CTA 10-benzyl-2,25-dicyano-13-isobutyl-5,8,11,14,17,22-hexaoxo-6,9,12,15,18,21-hexaazahexacosane-2,25-diyl dibenzodithioate
DCC N,N′-dicyclohexylcarbodiimide
DMAP 4-(dimethylamino) pyridine
EPI epirubicin
Fmoc-Abu(N3)-OH (S)-2-(Fmoc-amino)-4-azidobutanoic acid
HPMA N-(2-hydroxypropyl)methacrylamide
HATU 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxidhexafluorophosphate
HOBt 1-hydroxybenzotriazole
111In-P-EPI-125I frist generation HPMA copolymer-EPI conjugate with 111In-DTPA labeled polymer backbone and 125I-Tyr labeled EPI
111In-2P-EPI-125I second generation HPMA copolymer-EPI conjugate with 111In-DTPA labeled polymer backbone and 125I-Tyr labeled EPI
125I-2P-EPI-111In second generation HPMA copolymer-EPI conjugate with 125I-Tyr labeled polymer backbone and 111In-DTPA labeled EPI
MA-Tyr-NH2 N-methacryloyltyrosinamide
MA-GFLG-OH N-methacryloylglycylphenylalanylleucylglycine
MA-GFLG-Abu(N3)-OH N-(2-((4-azido-1-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)
tetrahydro-2H-pyran-4-yl)amino)-1-oxobutan-2-yl)amino)-2-oxoethyl)-2-(2-(2-methacrylamidoacetamido)-3-phenylpropanamido)-4-methylpentanamide
MA-GFLG-Abu(N3)-EPI N-(2-((4-azido-1-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)
oxy)tetrahydro-2H-pyran-4-yl)amino)-1-oxobutan-2-yl)amino)-2-oxoethyl)-2-(2-(2-methacrylamidoacetamido)-3-phenylpropanamido)-4-methylpentanamide
MA-GFLG-Abu(Tyr)-EPI 2-(4-(1-(12-benzyl-3-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,
11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)carbamoyl)-9-isobutyl-18-methyl-5,
8,11,14,17-pentaoxo-4,7,10,13,16-pentaazanonadec-18-en-1-yl)-1H-1,2,3-triazol-5-yl)butanamido)-3-(4-hydroxyphenyl)propanoic acid
MA-GFLG-NHBoc tert-butyl(11-benzyl-8-isobutyl-17-methyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadec-17-en-1-yl)carbamate
MA-GG-EPI N-(2-((2-(((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,
11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)methacrylamide
NH2-GFLG-NH2 2-(2-(2-aminoacetamido)-3-phenylpropanamido)-N-(2-((2-aminoethyl)amino)-2-oxoethyl)-4-methylpentanamide
p-SCN-Bn-DTPA 2,2′-((1-((2-((2-carboxyethyl)(carboxymethyl)amino)ethyl)(carboxymethyl)amino)-3-(4-thiocyanatophenyl)propan-2-yl)azanediyl)diacetic acid
P-EPI first generation HPMA and MA-GFLG-EPI copolymer conjugate
P-EPI-Tyr first generation HPMA and MA-GFLG-Abu(Tyr)-EPI copolymer conjugate
P-EPI-N3 first generation HPMA, APMA and MA-GFLG-Abu(N3)-EPI copolymer conjugate
P-DTPA-EPI(Tyr) first generation HPMA copolymer-EPI conjugate with DTPA pendent on polymer backbone and tyrosine moiety attachment with EPI
2P-EPI-N3 second generation HPMA, APMA and MA-GFLG-Abu(N3)-EPI copolymer conjugate
2P-DTPA-EPI(Tyr) second generation HPMA copolymer-EPI conjugate with DTPA pendent on polymer back bone and tyrosine moiety attachment with EPI
2P-Tyr-EPI-N3 second generation HPMA, MA-Tyr-NH2 and MA-GFLG-Abu(N3)-EPI copolymer conjugate
2P-Tyr-EPI(DTPA) second generation HPMA copolymer-EPI conjugate with tyrosine moiety pendent on polymer backbone and DTPA attachment with EPI
RAFT reversible addition-fragmentation chain transfer
TBTA tris(benzyltriazolylmethyl)amine
TFA trifluoroacetic acid
Hexynoic-Tyr 2-(hex-5-ynamido)-3-(4-hydroxyphenyl)propanoic acid
V-65 2,2′-azobis(2,4-dimethylvaleronitrile)
V-501 4,4-azobis (4-cyanopentanoic acid)
VA-044 2,2′-azobis[2-(2-imidazolin-2-yl) propane]dihydrochloride