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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2016 Apr 6;59(8):3635–3649. doi: 10.1021/acs.jmedchem.5b01718

Table 5.

Down-regulation of Gli1 mRNA in MERP MB cells.

Compounda IC50 (μM)b
ITZ 0.39 ± 0.06
17 0.26 ± 0.12
20 0.19 ± 0.07
21 0.29 ± 0.08
a

All analogues evaluated following 48 hr incubation.

b

IC50 values represent the Mean ± SEM of two separate experiments.