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. Author manuscript; available in PMC: 2016 Oct 12.
Published in final edited form as: Cancer Res. 2014 Jan 14;74(6):1822–1832. doi: 10.1158/0008-5472.CAN-13-1839

Figure 5.

Figure 5

PDGF-dependent gliomagenesis resulting from syngeneic engraftment of NSC (Id2). A, a schematic representation of orthotopic NSC engraftment procedure. B, Kaplan–Meier survival curve of WT mice orthotopically inoculated with NSC (v-GFP; n = 23) or NSC (Id2-GFP; n = 28) and sacrificed after developing severe neurologic symptoms. C, Kaplan–Meier survival curve of hPDGFB(+) mice orthotopically inoculated with NSC(v-GFP; n = 20) or NSC (Id2-GFP; n = 25), P < 0.001 determined using a log-rank (Mantel–Cox) test. D, the representative image of NSC (Id2-GFP)-induced tumor in an hPDGFB (+) mouse visualized using reflected light and GFP fluorescence. Scale bars, 2.5 mm.