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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Immunol. 2016 Jul 22;197(5):1926–1936. doi: 10.4049/jimmunol.1600162

Figure 1. A cryptic epitope is buried in native HSP90β.

Figure 1

(A) Sequence of human HSP90β immunoprecipitated by RA-ILD serum demonstrates 9 arginines targeted by in vitro citrullination (magenta) of whole cell extract as well as the remaining unmodified arginines (cyan) (29). (B) Homology model depicts the middle domain structure of HSP90β corresponding to residues 303–706. Six of the nine previously identified citrullination sites are shown as magenta spheres; other arginines are shown as cyan sticks. (C) Magnified view of boxed portion of (B) showing the region surrounding peptide 7/R502. While residues V585 and D631 are shown as sticks, the buried residue F499 is represented by spheres.