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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Immunol. 2016 Jul 22;197(5):1926–1936. doi: 10.4049/jimmunol.1600162

Figure 4. Increasing number of citrullines unfolds HSP90.

Figure 4

Plots of relative side chain solvent-accessible surface area (SASA) measurements for R502 (top row) and F499 (bottom row) over 1-μs conventional MD simulations for the middle domain of HSP90β (comprising residues 286–691) with no citrullines (A) versus 1-μs scaled MD simulations of the same domain with (B) no citrullines, (C) four citrulline modifications at R392, R604, R612, and R679, and (D) six citrulline modifications that include residues designated in (C) as well as R475 and R682.