TABLE 2.
Descriptive characteristics of cohorts 1 and 2 combined by locoregional progression.
| Patients Locoregional progression, No. (%) or median |
|||
|---|---|---|---|
| Characteristics | No (n = 122) | Yes (n = 18) | p value* |
| Median age at diagnosis (range), y | 59 (37–82) | 63 (47–81) | .17 |
| Sex: male/female | 92 (75)/30 (25) | 3 (17)/15 (83) | .46 |
| Lymph node stage treated (n = 129) N0/N+ | 30 (27)/81 (73) | 7 (39)/11 (61) | .30 |
| Primary tumor stage (n = 135) 1 or 2/3 or 4 | 63 (54)/54 (46) | 6 (33)/12 (67) | .11 |
| Disease site condensed (n = 134) | |||
| Oral cavity | 3 (3) | 1 (6) | |
| Oropharynx | 72 (61) | 7 (41) | |
| Hypopharynx | 8 (7) | 1 (6) | |
| Larynx | 34 (29) | 8 (47) | .37 |
| Median RT duration (range), d | 50 (38–79) | 53 (49–83) | <.01 |
| RT duration | |||
| ≤56 d | 111 (91) | 11 (61) | |
| ≥57 d | 11 (9) | 7 (39) | <.01 |
| Median pretreatment Hgb, (range) g/dL | 13.9 (8.60–19.40) | 12.45 (9.50–15.50) | .02 |
| Pretreatment Hgb, g/dL | |||
| <12 | 20 (16) | 7 (39) | |
| ≥12 | 102 (84) | 11 (61) | .11 |
| Median pretreatment weight, (range) kg | 80.55 (42.60–140.50) | 74.50 (46.80–141) | .26 |
| Pretreatment weight status | |||
| <90% IBW | 14 (11) | 6 (33) | |
| ≥90% IBW | 108 (89) | 12 (67) | .01 |
Abbreviations: RT, radiation therapy; Hgb, hemoglobin; g/dL, grams per deciliter; kg, kilograms; IBW, ideal body weight.
*
Fisher Exact Test or chi-square (2-tailed) was used to examine differences for categorical variables and Mann–Whitney U test (2-tailed) was used to examine differences for continuous variables.