. Author manuscript; available in PMC: 2016 Oct 12.

Published in final edited form as: J Immunol. 2013 Oct 14;191(10):4979–4988. doi: 10.4049/jimmunol.1301942

Table 1.

PGE₂ production in spleen of mPGES-1 null and WT mice

Immunization	PGE₂ (ng/mg protein)
Immunization	WT	nul
DNP-KLH (day 14)	5.14 ± 1.45	0.34 ± 0.08^**
DNP-KLH (day 28)	9.13 ± 1.94	0.61 ± 0.08^***
TNP-LPS (day 14)	6.72 ± 0.70	0.60 ± 0.08^***
DNP-Ficoll (day 14)	8.18 ± 0.27	0.74 ± 0.07^***

mPGES-1 WT and null mice were injected i.p. with T-cell dependent (TD) antigen DNP-KLH in CFA, T-cell independent type1 (TI-1) antigen TNP-LPS or T-cell independent type2 (TI-2) antigen DNP-Ficoll on day 0. Spleen was isolated at the indicated time point and the levels of PGE₂ were determined by ELISA. Data are expressed as the mean + SEM (n=4–11).

^{** and ***}

indicate statistical significance at P<0.01 and P<0.001, versus WT mice.