Table 3. Cox proportional hazard regression model with factors predicting overall survival for the entire cohort.
| univariate | multivariate | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p | HR* | 95% CI | p |
| ACE-27 score | ||||||
| None, 0 | Ref | Ref | ||||
| Mild, 1 | 1.91 | 1.03–3.55 | .041 | 2.05 | 0.82–5.13 | NS |
| Moderate, 2 | 2.59 | 1.46–4.60 | .001 | 2.30 | 1.00–5.32 | .050 |
| Severe, 3 | 2.74 | 1.41–5.34 | .003 | 4.30 | 1.63–11.32 | .003 |
| Cytogenetics | ||||||
| Good | Ref | Ref | ||||
| Intermediate | 1.53 | 0.69–3.40 | NS | 1.72 | 0.64–4.59 | NS |
| Poor | 3.01 | 1.30–6.97 | .010 | 4.40 | 1.62–11.93 | .004 |
| ECOG | ||||||
| 0–1 | Ref | Ref | ||||
| ≥ 2 | 3.18 | 1.96–5.16 | .000 | 3.12 | 1.47–6.61 | .003 |
| Age, years | ||||||
| < 60 | Ref | Ref | ||||
| ≥ 60 | 1.82 | 1.22–2.71 | .003 | 1.53 | 0.84–2.78 | NS |
| LDH, U/l | ||||||
| ≤ 700 | Ref | Ref | ||||
| > 700 | 2.17 | 1.48–3.19 | .000 | 1.28 | 0.70–2.34 | NS |
| WBC, /L | ||||||
| ≤ 30x109 | Ref | Ref | ||||
| > 30x109 | 1.57 | 1.07–2.28 | .020 | 1.51 | 0.90–2.64 | NS |
HR, hazard ratio; CI, confidence interval; ACE-27, Adult Comorbidity Evaluation-27; ECOG, Eastern Cooperative Oncology Group; WBC, white blood cell; LDH, lactate dehydrogenase; NS, not significant; Ref, reference.
*HR was adjusted to age, ACE-27, ECOG, cytogenetics, WBC and LDH.