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. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615

Fig 6. The F508del CFTR Band B pool available for correction can be increased by blocking of ubiquitination.

Fig 6

(A, B) Western blot of HeLa, CFBE, or HEK 293 lysates treated with PYR-41 (Selleck Chemicals). (C) Short circuit current (Isc) from CFBE monolayers treated with PYR-41, C18, or a combination of both compounds monitored by modified Ussing chamber analysis. N = 4 filters per condition. Error bars represent SEM with p values indicated. The change in Isc for each perturbation is shown. Values were normalized against combined Isc changes in the DMSO control, taken as 100%. (D) Effects of PYR-41 plus C18 in HEK 293 expressing the CFTR E92K mutation.