Figure 2.

Propagation of an AA mismatch through multiple replications, resulting in a TA mutation. The first iteration of replication results in an AA mismatch, shown in red. The mismatch can be processed and repaired by the MMR machinery shown at the bottom. If unprocessed, upon a second iteration of replication the mismatch will result in a mutation, shown in red. Newly synthesized DNA from the first iteration and second iterations are shown in blue and green, respectively.