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. Author manuscript; available in PMC: 2017 Jul 16.
Published in final edited form as: Horm Res Paediatr. 2016 Jul 16;86(2):126–130. doi: 10.1159/000447515

Figure 1.

Figure 1

A- Family pedigree showing the segregation of central precocious puberty (CPP) with the paternally inherited MKRN3 p.Pro161Argfs*16 mutation. B- Chromatograms showing the presence of the MKRN3 p.Pro161Argfs*16 mutation in the asymptomatic father (I.1) and in his two daughters who developed CPP (II.1 and II.2). C- Girl's stature-for-age growth chart (CDC) showing the increased growth in the reported girl (II.2) with CPP caused by the MKRN3 p.Pro161Argfs*16 mutation. D- Rapid breast development (Tanner B3) in a 6.7 year-old-girl (II.2) with CPP caused by the MKRN3 p.Pro161Argfs*16 mutation (the exhibition of this photography was authorized by patient's parents). TH: target height.