. Author manuscript; available in PMC: 2017 Jul 16.

Published in final edited form as: Horm Res Paediatr. 2016 Jul 16;86(2):126–130. doi: 10.1159/000447515

Table 1.

Time-course of the clinical and laboratory features of a prepubertal girl carrying a loss-of-function MKRN3 mutation who developed central precocious puberty.

Age (years)	Height (Z score)	Growth rate (cm/yr)	Tanner Stage	LH (mIU/mL)	FSH (mIU/mL)	Estradiol (pg/mL)	Δ Bone age (years)
5.7	0.4	NA	B1 PH1	ND	ND	ND	ND
6	0.5	9	B1 PH1	0.1	1.3	49.7	0.6
6.3	0.6	7.5	B1 PH1	0.4	5.9	41.3	ND
6.7	0.8	12	B3 PH1	0.9	3.3	54.1	0.7

Δ Bone age: difference between bone age and chronological age. NA: not available. B: breast. PH: pubic hair. ND: not done.

Normal prepubertal reference values (IQMA): LH <0.3 mIU/mL; Estradiol <20 pg/mL.