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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Biochem Pharmacol. 2016 Sep 8;119:76–84. doi: 10.1016/j.bcp.2016.09.003

Figure 1.

Figure 1

Activation of DABE, M1, and M2 by recombinant human CES1 and CES2. The concentrations of active metabolite DAB were determined after incubation of DABE, M1 or M2 with CES1 and CES2 at 37 °C for 5 min. The final protein concentration of the enzymes was 25 ng/μl, and the concentration of all three substrates was 200 nM. Data are expressed as the rates of DAB formation (Mean ± S.D., n=3).