Table 2.

Recently published case reports of Ciprofloxacin^R Aeromonas spp. cultured in association with medicinal leech therapy.

Reference	No. of case reports	Patient case conditions	Prophylaxis used	Treatment that cleared infection	Isolate(s) cultured	Geographic location	Year published
Wang et al., 2011	1	Mandibulectomy with planned tissue flap reconstruction, infection and necrosis of the flap	Ciprofloxacin	Cefepime	A. hydrophila	Missouri, USA	2011
Sartor et al., 2013	1	Infection of skin flap of hand crush injury	Ciprofloxacin	Cotrimoxazole	A. hydrophila	Marseille, France	2013
Giltner et al., 2013	1	Mandibular osteotomy, necrosis of mandibular flap and wound surrounding the distraction arm device	Ciprofloxacin	Vancomycin	A. hydrophila, Morganella morganii	California, USA	2013
Wilmer et al., 2013	1	Amputation of three digits and necrosis of amputation sites	Ciprofloxacin	Co-trimoxazole	A. hydrophila	British Columbia, Canada	2013
Patel et al., 2013	1	Breast reconstruction, infection of the implant	Ciprofloxacin, vancomycin	Aztreonam	A. hydrophila	Washington D.C., USA	2013
van Alphen et al., 2014	2	Replantation of four fingers resulting in flap necrosis after leech therapy, followed by amputation	Ertapenem	Ceftriaxone and co-trimoxazole	A. hydrophila	Minnesota, USA	2014
		Replantation of two fingers failed following leech therapy, amputation	Ciprofloxacin	Cefepime, metronidazole, vancomycin; followed by ceftriaxone	A. hydrophila, Proteus vulgaris, Morganella morganii