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Putative mechanism of action of PDE9 inhibition for strengthening synaptic plasticity. AMPA‐R, α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor; cGMP, cyclic guanosine monophosphate; GMP, guanosine‐5′‐monophosphate; GTP, guanosine‐5′‐triphosphate; NMDA‐R, N‐methyl‐D‐aspartate receptor; NO, nitric oxide; NOS, nitric oxide synthase; pCREB, phosphorylated cyclic adenosine monophosphate response element binding protein; PDE9, phosphodiesterase 9; sGC, soluble guanylyl cyclase
