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. 2016 Aug 22;82(5):1315–1324. doi: 10.1111/bcp.13060

Figure 4.

Figure 4

Geometric mean drug plasma concentration–time profiles after administration of 0.5–350 mg BI 409306 to cytochrome P450 2C19‐genotyped extensive metabolizers and poor metabolizers. EM, extensive metabolizers; PM, poor metabolizers. Inline graphic 0.5 mg solution EM (n = 6), Inline graphic 5 mg solution EM (n = 6), Inline graphic 10 mg tablet EM (n = 6), Inline graphic 50 mg tablet EM (n = 6), Inline graphic 100 mg tablet EM (n = 5), Inline graphic 350 mg tablet EM (n = 6), Inline graphic 100 mg tablet PM (n = 6), Inline graphic 2 mg solution EM (n = 6), Inline graphic 5 mg tablet EM (n = 6), Inline graphic 25 mg tablet EM (n = 6), Inline graphic 50 mg solution EM (n = 8), Inline graphic 200 mg tablet EM (n = 6), Inline graphic 10 mg tablet PM (n = 6)