Table 3.
Parameter | Value* | Bootstrap median (2.5th, 97.5th)† |
---|---|---|
Baseline E0 ‡, % | 56 | 56 (55, 56) |
IIV (additive) | 11 | 11 (10, 11) |
Saturation | ||
IC50 (mg l–1) | 0.0135 (FIXED)§ | ‐‐‐ |
Hill coefficient (γ) | 1 (FIXED)§ | ‐‐‐ |
Desaturation | ||
IC50 (mg l–1) | 2.07 | 2.02 (1.50, 2.39) |
IIV, % | 47 | 47 (36, 79) |
Hill coefficient (γ) | 4.44 | 4.35 (3.19, 5.19) |
Residual error (additive) | 4.02 | 4.03 (3.13, 4.72) |
Summary from 1454 successful runs out of 2000 runs;
Percentage of CD4+ T cells staining positive for unoccupied CD25;
IC 50 and γ fixed as that estimated using OBSERVE intensive subgroup PK data and 1, respectively;
ETA shrinkages for baseline E0 and desaturation IC 50 are 10.4% and 76.1%, respectively. EPS shrinkage for additive residual error is 9.1%