Table 3.

Summary of CD25 occupancy model

Parameter	Value*	Bootstrap median (2.5th, 97.5th)†
Baseline E0 ‡, %‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬	56	56 (55, 56)
IIV (additive)	11	11 (10, 11)
Saturation
IC50 (mg l–1)	0.0135 (FIXED)§	‐‐‐
Hill coefficient (γ)	1 (FIXED)§	‐‐‐
Desaturation
IC50 (mg l–1)	2.07	2.02 (1.50, 2.39)
IIV, %	47	47 (36, 79)
Hill coefficient (γ)	4.44	4.35 (3.19, 5.19)
Residual error (additive)	4.02	4.03 (3.13, 4.72)

^† Summary from 1454 successful runs out of 2000 runs;

^‡ Percentage of CD4+ T cells staining positive for unoccupied CD25;

^§ IC ₅₀ and γ fixed as that estimated using OBSERVE intensive subgroup PK data and 1, respectively;

^* ETA shrinkages for baseline E₀ and desaturation IC ₅₀ are 10.4% and 76.1%, respectively. EPS shrinkage for additive residual error is 9.1%