Figure 1.

Simplified scheme of the mechanism of action of mTOR inhibitors such as sirolimus and everolimus and novel mTORC1/mTORC2 dual inhibitors. AKT protein kinase B; mLST8 mammalian lethal with SEC13 protein 8; mSIN1 mammalian stress‐activated protein kinase‐interacting protein 1; mTOR mechanistic target of rapamycin; mTORC mTOR complex; PI3K phosphatidylinositide 3‐kinase; Raptor regulatory‐associated protein of mTOR; Rictor rapamycin‐insensitive companion of mammalian target of rapamycin