Table 3.
Univariate Cox regression analysis of mortality (8.9%) and hospitalization (31.0%) in association with inappropriate prescribing in a cohort of oldest old (n = 503)
| Mortality | Hospitalization | |||
|---|---|---|---|---|
| Continuous | Range | HR (95% CI) | HR (95% CI) | |
| Number of mediations | 0–21 | 1.12 (1.02, 1.22) | 1.14 (1.08, 1.20) | |
| Underuse | 0–5 | 1.43 (1.15, 1.78) | 1.35 (1.19, 1.54) | |
| Misuse | 0–6 | 1.16 (0.92, 1.47) | 1.20 (1.06, 1.36) | |
| Interaction effects | ||||
| Underuse*Misuse | 0–24 | 1.07 (1.00, 1.15) | 1.08 (1.04, 1.12) | |
| Categorical | Cut‐offs | n | MortalityHR (95% CI) | Hospitalization HR (95% CI) |
|---|---|---|---|---|
| Underuse | 0 | 166 | 1 | 1 |
| 1–2 | 265 | .89 (.43, 1.86) | 1.17 (.81, 1.71) | |
| 3 or more | 72 | 3.33 (1.58, 7.04) | 2.79 (1.79, 4.34) | |
| Misuse | 0 | 221 | 1 | 1 |
| 1–2 | 235 | 1.52 (0.80, 2.90) | 1.33 (0.95, 1.86) | |
| 3 or more | 47 | 1.95 (0.7, 5.03) | 1.49 (0.87, 2.55) |
The associations of inappropriate prescribing were first tested, using the continuous variables for underuse and misuse. Using categorical analysis, trends were explored for a higher risk for mortality or hospitalization with a higher degree of underuse or misuse