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The mammalian target of rapamycin (mTOR) complex (mTORC1) signalling pathway contributes to ageing through various cellular processes. Active mTORC1 activates stem cell turnover, cellular senescence and protein translation (arrows), while it inhibits autophagy. These conditions contribute to the ageing of an organism. See text for details. FKBP38, FK‐506‐binding protein; mLST8, mammalian lethal with sec‐13 protein 8; PRAS40, proline‐rich Akt substrate of 40‐kDa
