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. 2016 Oct 13;7:360. doi: 10.3389/fphar.2016.00360

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Copyright © 2016 Kaur, Padiya, Adela, Putcha, Reddy, Reddy, Kumar, Chakravarty and Banerjee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Photomicrographs of rat liver, H&E, 20× Liver section of control rat (A) illustrating central vein (CV) with endothelial lining (arrows), hepatocytes and sinusoidal spaces with Kupffer cells. Liver section of diabetic rat (B1,2) showing loss of the normal architecture due to distended central veins in different areas with lots of leucocytic infiltrations into the vein and in between vacuolations (yellow arrows) as damage hallmarks. The liver sections from diabetic animals treated with garlic (C), resveratrol (D), or metformin (E) showed overall remarkable recovery changes toward normal histology with few exceptions (D). Note still remains of few leucocytic infiltrations to CV in garlic treated group (C), and slightly more vacuole spaces in metformin treated diabetic animals (arrows in E) than control.