A—HUMAN STUDIES
Study reference	Type of Substance and duration of usage	Type of study	Study population	Underlying disease	Results (addicts compared to non-addicts)
					BMI	BP	Prevalence of hypertension
Roohafza et al., 2013	Opium addicted	Cohort	n = 569 men (99 opium addicts, 470 non-addicts)	AMI	↔	↔	ND
Hosseini et al., 2011	Opium	Cross-sectional	n =456 men/women (228 opium addict, 228 non-addict)	Diabetes mellitus	↔	↔	↔
Aghadavoudi et al., 2015	Opium (for 12.6 ± 7.7 years)	Cross-sectional	n = 325 men/women (117 opium abuser, 208 non-abuser)	CAD	↓	↔	↓
Rahimi et al., 2014	Opium addicted	Cross-sectional	n = 374 men/women (179 opium user, 195 non-user)	Diabetes mellitus	↓	↑	↔
Masoomi et al., 2015	Opium addicted	Cross-sectional	n = 217 men (103 opium addict, 114 non-addict)	None	ND	↓	↔
Mansour et al., 1970	Morphine (15 mg/kg single dose)	Inter-ventional	Not reported	None	ND	↓	ND
Yousefzadeh et al., 2015	Opium (for 11.8 years)	Cross-sectional	n = 5332 men/women (811 current opium users, 176 former opium users. 4340 non-user)	None	↓	ND	↑
Bayani et al., 2014	Opium (for more Than 6 months)	Cross-sectional	n = 97 men/women (48 opium addicts, 49 non-addicts)	ACS + type 2 diabetes	↔	ND	↔
Najafi and Sheikhvatan, 2012a	Opium addicted	Cross-sectional	n = 232 (26 opium addicts, 206 non-addicts)	advanced CAD+ type 2 diabetes	↓	ND	↔
Javadi et al., 2014	Opium addicted	Cross-sectional	n = 304 men/women (152 opium user, 152 non-user)	AMI	ND	ND	↔
Najafipour et al., 2015a	Opium addicted	Cross-sectional	n = 5896 men/women (non-users, occasional users, dependent users)	None	↔	ND	↔
Davoodi et al., 2005	Opium	Cohort	n = 160 (45 opium-dependent, 115 non-dependent)	AMI	ND	ND	↔
Shirani et al., 2010	Opium addicted	Cross-sectional	n =939 men/women(opium addicts, and non-addicts)	CAD	↓	ND	↓
Masoomi et al., 2008	Opium	Cross-sectional	n = 240 men/women (126 opium addict, 114 non-addict)	AMI	ND	ND	↔
Dehghani et al., 2013	Opium	Cross-sectional	n = 460 men/women (239 opium addict, 221 non-addict)	AMI	ND	ND	↓
Najafi and Sheikhvatan, 2012b	Opium addicted	Cross-sectional	n = 268 men/women (38 opium addict, 230 non-addict)	CAD	↓	ND	↔