B—ANIMAL STUDIES
Study reference	Animal	Type of substance and duration of usage	Study population	Underlying disease	Results (addicts compared to non-addicts)
					FBS	HbA1c
Mohammadi et al., 2012	Mouse	Opium (orally for 1 month)	n = 16 (8 opium addict, 8 non-addict)	None	↔	ND
Sadeghian et al., 2009	Rat	Opium (orally for 1 month)	n = 20 male (10 addict, 10 non-addict)	Diabetes mellitus	↔	↔
Mami et al., 2011	Rabbit	Opium (orally for 60 days)	n = 40 (20 addict, 20 non-addict)	None	↑	ND
Sadava et al., 1997	Rat	Methadone (orally for 35 days)	n = 70 female (35 addict, 35 control)	None	↑	ND

Symbols: ↓, decrease; ↑, increase; ↔, no difference; ^#, addicted males compared to control males; ^*, opium addicted compared to control.

FBS, fasting blood sugar; HbA1c, glycated hemoglobin; ND, not detected; None, no disease; AMI, acute myocardial infarction; CAD, coronary artery disease.