Figure 2.
Radiosensitising effect of vorinostat. Survival fraction following irradiation (IR) under normoxia and combinations of vorinostat (1 μM, 24 h) and hypoxia exposure (0.2% O2, 24 h) in DU 145 (A), PC-3 (B) and 22Rv1 (C) prostate cancer cell lines. Points represent mean value from at least three independent experiments, and bars depict s.e.m. *Statistically significant difference compared with normoxia solvent control; **statistically significant differences compared with hypoxia solvent control.