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Association of LD breakdown with displacement from nearest functional element, namely CpG islands and TSS. There is a strong negative correlation between the distance from the functional elements and LDU/kb (ρ=−0.12 for CpG islands, ρ=−0.10 for TSS, P<2.2 × 10−16 for each comparison). Shown is the mean LDU/kb ratio for 5 kb bins, and shaded area indicates 95% confidence interval.
