Table 4. Melanopsin sites identified by Bayes empirical Bayes analysis as coming from the class of divergent sites under the CmC_Pa model (PP cutoff=70%).

Amino acid site	PP	Protein domain
34	0.73301	Extracellular
37	0.83092	Extracellular
45	0.81544	Extracellular
50	0.712	Extracellular
69a	0.9634	Transmembrane 1
160	0.77478	Transmembrane 3
162a	0.78929	Cytoplasmic
188	0.70835	Transmembrane 4
192	0.70139	Transmembrane 4
202a	0.73608	Transmembrane 4
205a	0.76531	Extracellular
235	0.70811	Transmembrane 5
261	0.72722	Cytoplasmic
265	0.73131	Cytoplasmic
271	0.7328	Cytoplasmic
274	0.79893	Cytoplasmic
285a	0.76222	Cytoplasmic
343a	0.81869	Transmembrane 7
366	0.70826	Cytoplasmic
370	0.71896	Cytoplasmic
376	0.8297	Cytoplasmic
397	0.78226	Cytoplasmic

Abbreviation: PP, posterior probability.

^aAmino acid changes specific of Phreatichthys andruzzii branch. The amino acid changes predicted to be deleterious by Panther and SIFT analyses are underlined (Supplementary Table 6).