Table 2.
Muscle ceramide subspecies and total content before and after 10 weeks of endurance training in T2D offsprings and matched controls.
| Ceramide | Control (n = 16) |
Offspring (n = 19) |
p value | |||||
|---|---|---|---|---|---|---|---|---|
| Subspecies | Pre | Post | % Δ | Pre | Post | % Δ | Training main effect | Training × group interaction |
| C14:0 | 0.0052 ± 0.0010 | 0.0046 ± 0.0007 | −11.5 | 0.0042 ± 0.0009 | 0.0057 ± 0.0011 | 35.1 | 0.335 | 0.268 |
| C16:0 | 0.41 ± 0.06 | 0.27 ± 0.04 | −33.2 | 0.38 ± 0.09 | 0.37 ± 0.05 | −3.22 | 0.251 | 0.082 |
| C18:0 | 5.67 ± 0.36 | 5.55 ± 0.68 | −2.08 | 6.06 ± 0.58 | 6.04 ± 0.27 | −0.28 | 0.830 | 0.426 |
| C18:1 | 0.12 ± 0.02 | 0.11 ± 0.02 | −12.4 | 0.11 ± 0.01 | 0.11 ± 0.01 | 5.80 | 0.670 | 0.292 |
| C20:0 | 0.046 ± 0.014 | 0.031 ± 0.004 | −32.0 | 0.029 ± 0.003 | 0.029 ± 0.003 | −0.01 | 0.384 | 0.286 |
| C22:0 | 1.63 ± 0.11 | 1.39 ± 0.14∗ | −14.8 | 1.38 ± 0.08 | 1.29 ± 0.08∗ | −6.93 | 0.017∗ | 0.294 |
| C24:0 | 0.0041 ± 0.0008 | 0.0036 ± 0.0016 | −11.5 | 0.0033 ± 0.0007 | 0.0044 ± 0.0008 | 35.1 | 0.335 | 0.268 |
| C24:1 | 3.81 ± 0.21 | 3.84 ± 0.29 | 0.94 | 3.58 ± 0.18 | 3.27 ± 0.24 | −8.71 | 0.251 | 0.323 |
| Mean % Δ | −14.6 ± 4.4 | 7.11 ± 6.3 | ||||||
| Total cer. | 11.7 ± 0.6 | 11.2 ± 1.1 | −4.27 | 11.6 ± 0.8 | 11.1 ± 0.5 | −4.31 | 0.272 | 0.579 |
Data are means ± SEM. All data are given as pmol/mg wet weight. The statistics are based on log10 due to failed normality testing. ∗Pre versus post main effect, (p = 0.017). The % delta calculated as the relative change from baseline.