FIGURE 5.

The growth of KMV-like phage phiNFS on lawn of plaquing P. aeruginosa clinical isolate inhibits plaque formation. The different activities of diffusible products can be observed: (a) complete inhibition of plaquing; (b) a significant reduction in the size of the plaques to a certain size; (c) an abrupt discontinuation of interaction. This is an example of a phage–host interaction which can seriously influence the results of phage therapy by enhancing bacterial growth in lung biofilm. Only specially prepared phage mixture can prevent undesirable effects of mono phage therapy.