Table 2.
Primary and secondary outcomes in overall analysis. Values are numbers in corticosteroid group versus numbers in control group, or means (standard deviations). Summary measures are relative risks (95% confidence intervals) unless stated otherwise
| Outcomes | Stutchfield et al 200511 | Balci et al 201015 | Porto et al 201112 | Ahmed et al 201513 | Gyamfi-Bannerman et al 201614 | Nada et al 201616 | I2 (%) | τ2 | Summary measure (95% CI) DL | Summary measure (95% CI) HKSJ |
|---|---|---|---|---|---|---|---|---|---|---|
| Severe RDS | 1/373 v 5/446 | N/R | 2/143 v 1/130 | 0/228 v 2/224 | 20/1427 v 34/1400 | N/R | 0 | 0.00 | 0.55 (0.33 to 0.91) | 0.55 (0.31 to 0.98) |
| RDS | 11/373 v 24/446 | 8/50 v 2/50 | 36/143 v 30/130 | 18/228 v 52/224 | 79/1427 v 89/1400 | 4/616 v 10/611 | 0 | 0.00 | 0.74 (0.61 to 0.91) | 0.74 (0.46 to 0.98) |
| Mild RDS | 4/373 v 9/446 | N/R | N/R | 16/228 v 38/224 | 31/1427 v 28/1400 | N/R | 72 | 0.33 | 0.67 ( (0.46 to 0.96) | 0.67 (0.38 to 0.98) |
| Moderate RDS | 6/373 v 10/446 | N/R | N/R | 2/228 v 12/224 | N/R | N/R | 63 | 0.75 | 0.39 (0.18 to 0.89) | 0.39 (0.08 to 0.95) |
| Transient tachypnea of the newborn | 10/373 v 19/446 | N/R | 34/143 v 29/130 | 18/228 v 50/224 | 95/1427 v 138/1400 | 8/616 v 21/611 | 66 | 0.14 | 0.56 (0.37 to 0.86) | 0.56 (0.22 to 0.93) |
| Use of surfactant | N/R | N/R | 1/143 v 0/130 | N/R | 26/1427 v 43/1400 | N/R | 0 | 0.00 | 0.61 (0.38 to 0.99) | 0.61 (0.21 to 1.21) |
| Mask ventilation | 15/373 v 17/446 | 16/50 v 7/50 | 26/143 v 23/130 | N/R | 145/1427 v 184/1400 | N/R | 61 | 0.13 | 0.85 (0.69 to 1.04) | 0.85 (0.42 to 1.31) |
| Mechanical ventilation | 2/373 v 17/446 | N/R | 2/143 v 1/130 | N/R | 34/1427 v 43/1400 | 5/616 v 21/611 | 65 | 0.84 | 0.52 (0.36 to 0.76) | 0.52 (0.24 to 0.89) |
| Time receiving oxygen (hours) | 0.74 (0.43) v 2.80 (1.12) | N/R | N/R | N/R | N/R | N/R | NA | NA | −2.06* (−2.17 to −1.95) | −2.06* (−2.17 to −1.95) |
| Maximum inspired oxygen concentration (%) | 21.27 (0.16) v 21.93 (0.33) | N/R | N/R | N/R | N/R | N/R | NA | NA | −0.66* (−0.69 to −0.63) | −0.66* (−0.69 to −0.63) |
| Admission to NICU | 26/373 v 32/446 | 8/50 v 2/50 | 47/143 v 43/130 | 2/228 v 12/224 | 593/1,427 v 627/1400 | 10/616 v 24/611 | 56 | 0.05 | 0.81 (0.54 to 1.20) | 0.81 (0.40 to 1.34) |
| Length of stay in NICU (days) | 0.14 (0.05) v 9.30 (0.05) | N/R | N/R | 1.11(0.03) v 3.81 (0.09) | N/R | N/R | 83 | 0.66 | −7.64* (−7.65 to −7.64) | 7.64* (−7.69 to −7.61) |
| APGAR score at 1 min | 8.53 (0.07) v 8.59 (0.05) | 7.40 (0.85) v 7.86 (0.78) | N/R | N/R | N/R | N/R | 83 | 0.07 | 0.06* (0.05 to 0.07) | 0.06* (0.04 to 0.08) |
| APGAR score at 5 min | 9.36 (0.05) v 9.30 (0.05) | 7.98 (0.74) v 8.60 (0.75) | N/R | N/R | N/R | N/R | 83 | 0.22 | 0.06* (0.05 to 0.07) | 0.06* (0.04 to 0.08) |
| Neonatal hypoglycemia | N/R | N/R | 15/143 v 9/130 | N/R | 343/1427 v 209/1400 | N/R | 0 | 0.00 | 1.61 (1.38 to 1.87) | 1.61 (1.04 to 3.13) |
| Neonatal death | 0/373 v 0/446 | 0/50 v 0/50 | 0/143 v 2/130 | 0/228 v 0/224 | 2/1427 v 0/1400 | 1/616 v 2/611 | 0% | 0.00 | 0.77 (0.21 to 2.83) | 0.77 (0.15 to 4.21) |
Emboldened data are statistically significant.
DL=DerSimonian and Laird; HKSJ=Hartung-Knapp-Sidik-Jonkman; NA=not applicable; RDS=respiratory distress syndrome; NICU=neonatal intensive care unit; N/R=data not reported in original trial.
*Mean difference.