Table 3.
Primary and secondary outcome in trials on steroids for women at risk of imminent late premature delivery at 340-366 weeks. Values are numbers in corticosteroid group versus numbers in control group, or means (standard deviations). Summary measures are relative risks (95% confidence intervals) unless stated otherwise
Outcomes | Balci et al 201015 | Porto 201112 | Gyamfi-Bannerman et al 201614 | I2 (%) | τ2 | Summary measure (95% CI) DL | Summary measure (95% CI) HKSJ |
---|---|---|---|---|---|---|---|
Severe RDS | N/R | 2/143 v 1/130 | 20/1427 v 34/1400 | 0 | 0.00 | 0.60 (0.33 to 0.94) | 0.60 (0.24 to 0.98) |
RDS | 8/50 v 2/50 | 36/143 v 30/130 | 79/1427 v 89/1400 | 0% | 0.00 | 0.98 (0.77 to 1.24) | 0.98 (0.44 to 1.32) |
Mild RDS | N/R | N/R | 31/1427 v 28/1400 | NA | NA | 1.09 (0.66 to 1.80) | 1.09 (0.31 to 1.47) |
Moderate RDS | N/R | N/R | N/R | - | - | - | - |
Transient tachypnea of the newborn | N/R | 34/143 v 29/130 | 95/1427 v 138/1400 | 9 | 0.08 | 0.72 (0.56 to 0.92) | 0.72 (0.50 to 0.98) |
Use of surfactant | N/R | 1/143 v 0/130 | 26/1427 v 43/1400 | 0 | 0.00 | 0.61 (0.38 to 0.99) | 0.61 (0.21 to 1.03) |
Mask ventilation | 16/50 v 7/50 | 26/143 v 23/130 | 145/1427 v 184/1400 | 0 | 0.00 | 0.83 (0.67 to 1.02) | 0.83 (0.59 to 1.16) |
Mechanical ventilation | N/R | 2/143 v 1/130 | 34/1427 v 43/1400 | 0 | 0.00 | 0.80 (0.51 to 1.24) | 0.80 (0.42 to 1.30) |
Time receiving oxygen (hours) | N/R | N/R | N/R | - | - | - | - |
Maximum inspired oxygen concentration (%) | N/R | N/R | N/R | - | - | - | - |
Admission to NICU | 8/50 v 2/50 | 47/143 v 43/130 | 593/1427 v 627/1400 | 52 | 0.45 | 0.94 (0.87 to 1.02) | 0.94 (0.73 to 1.15) |
Length of in NICU (days) | N/R | N/R | N/R | - | - | - | - |
APGAR score at 1 min | 7.40 (0.85) v 7.86 (0.78) | N/R | N/R | NA | NA | −0.46* (−0.78 to 0.14) | −0.46* (−0.78 to 0.14) |
APGAR score at 5 min | 7.98 (0.74) v 8.60 (0.75) | N/R | N/R | NA | NA | −0.62* (−0.91 to 0.33) | −0.62* (−0.91 to 0.33) |
Neonatal hypoglycemia | N/R | 15/143 v 9/130 | 343/1427 v 209/1400 | 0 | 0.00 | 1.61 (1.38 to 1.87) | 1.61 (1.16 to 2.12) |
Neonatal death | 0/50 v 0/50 | 0/143 v 2/130 | 2/1427 v 0/1400 | 0 | 0.00 | 0.95 (0.20 to 4.58) | 0.95 (0.15 to 5.87) |
Emboldened data are statistically significant.
DL=DerSimonian and Laird; HKSJ=Hartung-Knapp-Sidik-Jonkman; RDS=respiratory distress syndrome; NICU=neonatal intensive care unit; N/R=data not reported in original trial; NA=not applicable.
*Mean difference.