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. 2016 Oct 13;6:34651. doi: 10.1038/srep34651

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The CR-filtering workflow. (b) The length distribution of the filtered CR regions. (c) The number of CRs with different number of overlapping TAD boundaries. (d) The FDR of the top predicted CRs. (e) The scatterplot of Insulation Score vs. Enhancer Score. Black points represent the CR events with top 5% highest SI score. The red point represents a CR associated with polydactyly disease. (f) The overlap between top 5% predicted CRs using different cell lines.