Figure 2. Sequences of grafted peptides with corresponding epitopes and native cyclic peptide frameworks.

First-generation grafted cyclic peptides were designed with a single anti-angiogenic epitope inserted into a single loop. For the second-generation grafted cyclic peptides, two anti-angiogenic epitopes were inserted into two separate loops. Chosen anti-angiogenic epitopes are highlighted in bold. d-tryptophan is represented by ‘w’.