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. 2016 Oct 13;6:35347. doi: 10.1038/srep35347

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The percentage of HUVEC migration was analyzed using Prism Version 6 (GraphPad). (A–T) VEGF was used as a positive control with 100% HUVEC migration. All peptides were tested at concentrations ranging from 0.001–50 μM except for cilengitide and octreotide, which were tested in 10-fold dilutions from 10 μM. Peptides were added in the presence of 0.3 nM VEGF (bottom chamber). Data are shown as mean ± SD (n ≥ 3). Data were normalized to the mean VEGF control. P-values are represented as follows: ****p ≤ 0.0001, ***p ≤ 0.001, **p ≤ 0.01, and *p ≤ 0.05. A one-way ANOVA with Dunnett’s post-test using a multiple comparison test was used for statistical analysis.