Table 1. Cell proliferation inhibitory activity of all grafted and native peptides on HUVECs and cancer cells.
| Peptides | IC50 (μΜ) ± S.D.; 48 hours |
|||
|---|---|---|---|---|
| HUVEC | MCF-7 | PC3 | HT-29 | |
| SST-01 | 57.54 ± 0.04 | >100 | >100 | >100 |
| SFTI-SST-01 | 18.32 ± 0.05 | 46.07 ± 0.05 | >100 | 45.38 ± 0.03 |
| MCo-SST-01 | 17.12 ± 0.05 | >100 | 85.44 ± 0.08 | 74.13 ± 0.07 |
| SST-02 | >100 | >100 | >100 | >100 |
| SFTI-SST-02 | >100 | 55.13 ± 0.07 | >100 | 43.29 ± 0.04 |
| MCo-SST-02 | >100 | 70.61 ± 0.11 | 83.55 ± 0.20 | 58.89 ± 0.09 |
| PEDF | 19.40 ± 0.08 | >100 | >100 | >100 |
| SFTI-PEDF | 27.89 ± 0.11 | >100 | >100 | >100 |
| MCo-PEDF | 50.16 ± 0.15 | 53.44 ± 0.14 | 39.11 ± 0.07 | 35.22 ± 0.08 |
| polyR | 44.64 ± 0.03 | 83.51 ± 0.46 | >100 | >100 |
| SFTI-polyR-L1 | >100 | 28.72 ± 0.15 | >100 | 82.27 ± 0.13 |
| SFTI-polyR-L2 | >100 | 41.84 ± 0.07 | >100 | >100 |
| MCo-polyR-L1 | >100 | >100 | >100 | >100 |
| MCo-polyR-L6 | 34.95 ± 0.03 | >100 | >100 | 52.89 ± 0.11 |
| MCoAA-01 | 10.83 ± 0.09 | 45.01 ± 0.16 | >100 | 40.12 ± 0.13 |
| MCoAA-02 | 27.06 ± 0.06 | >100 | 35.44 ± 0.13 | 19.75 ± 0.07 |
| SFTI-1 | >100 | >100 | >100 | >100 |
| MCoTI-II | >100 | >100 | >100 | >100 |
| cilengitide | 4.69 ± 0.06 | >100 | >100 | 84.68 ± 0.13 |
| octreotide | >100 | >100 | >100 | >100 |
| sunitinib | 19.10 ± 0.46 | 17.07 ± 0.11 | 16.24 ± 0.26 | 1.43 ± 0.24 |