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. 2016 Oct 13;6:34956. doi: 10.1038/srep34956

Figure 4. Gas2 deficiency disrupts follicular development.

Figure 4

Representative images of H&E stained sections of ovaries collected from wild type (A) and mutant (B) mice at six weeks of age. A – Antral Follicle, LA – Large Antral Follicle, CL – Corpus Luteum, S – Stromal tissue. Gas2 null mice had fewer large antral follicles and corpora lutea compared to wild type. Further examination revealed that compared to wild type mice, follicles and CLs in Gas2 null females had less defined boundaries and more disorganized stromal cell structures immediately surrounding follicles and CLs. (C) The number of follicles at different stages of development was quantified as a percent of the total number of follicles. Gas2 null females had significantly percentage of large antral follicles (*p = 0.02835 n = 8) (Primordial p = 0.130, Primary p = 0.193, Secondary p = 0.485, Antral p = 0.341, n = 8). (D) Ovaries were also collected from wild type and Gas2 null mice superovulated at six weeks of age and the numbers of CLs were counted. The number of CLs were significantly reduced in the Gas2 null mutant compared to wild type mice (p = 0.001, n = 10).