Table 1. Study design and statistical characteristics of included studies on MRCP, S-MRCP and EUS.

Author	Year	Location	Patients	Mean age (yr)	Men/Female	Reference standard	Tertiary center	TP	FP	FN	TN	Sens (%)	Spec (%)
MRCP
Kushnir VM et al.16	2013	USA	31	53	19/12	ERCP	Yes	9	1	6	15	60.0	93.8
Carnes ML et al.17	2008	USA	111	60	84/27	ERCP	Partly	39	0	57	15	40.6	100
Kamisawa T et al.18	2007	Japan	32	NS	NS	ERCP	Yes	11	0	4	17	73.3	100
Lai R et al.19	2004	USA	43	51	NS	ERCP	Yes	3	4	2	34	60	89.5
Manfredi R et al.20	2002	Italy	15	11.3	NS	ERCP	Yes	0	0	3	12	0	100
Matos C et al.21	2001	Belgium	279	51.4	171/108	ERCP	Yes	22	1	7	249	75.9	99.6
Manfredi R et al.10	2000	Italy	107	48	56/51	ERCP	Yes	4	1	5	97	44.4	99.0
Ueno E et al.22	1998	Japan	93	NS	NS	ERCP	Yes	4	0	5	84	44.4	100
Bret PM et al.23	1996	Canada	108	NS	NS	ERCP	Yes	6	0	0	102	100	100
Soto JA et al.24	1995	USA	37	53	14/23	ERCP	Yes	4	0	2	31	66.7	100
S-MRCP
Mosler P et al.25	2012	USA	113	47.1	54/59	ERCP	Yes	14	3	5	91	73.7	96.8
Carnes ML et al.17	2008	USA	111	60	84/27	ERCP	Yes	10	0	5	96	66.7	100
Manfredi R et al.20	2002	Italy	15	11.3	NS	ERCP	Yes	2	0	1	12	66.7	100
Matos C et al.21	2001	Belgium	279	51.4	171/108	ERCP	Yes	29	1	1	248	96.7	99.6
Manfredi R et al.10	2000	Italy	107	48	56/51	ERCP	Yes	8	3	1	95	88.9	96.9
EUS
Kushnir VM et al.16	2013	USA	45	53.8	13/32	ERCP	Yes	39	0	6	3	86.7	100
Romagnuolo J et al.26	2013	USA	36	55	16/20	ERCP	Yes	18	1	3	3	85.7	75
Rana SS et al.27	2013	India	146	36.9	102/44	ERCP	Yes	16	4	0	126	100	96.9
Ortega AR et al.28	2011	Spain	49	58	24/25	Unclear	Yes	1	0	3	45	25	100
Lai R et al.19	2004	USA	127	51	NS	ERCP	Yes	18	3	1	105	94.7	97.2
Tandon M et al.29	2001	USA	31	48.8	12/19	ERCP	Partly	2	0	1	28	66.7	100
Bhutani MS et al.30	1999	USA	36	NS	NS	ERCP	Yes	4	5	2	25	66.7	83.3