Table 2. Quality Assessment Tool for Diagnostic Accuracy Systematic Review to evaluate the quality of selected studies.

Study	C1	C2	C3	C4	C5	C6	C7	C8	C9	C10	C11	C12	C13	C14
Kushnir VM et al.16	√	√	√	√	√	√	√	√	√	?	?	√	√	√
Romagnuolo J et al.26	√	√	√	√	×	×	√	√	×	√	√	√	√	×
Rana SS et al.27	√	√	√	√	×	×	√	√	√	×	×	√	√	√
Mosler P et al.25	√	√	√	√	√	√	√	√	√	?	?	√	√	√
Ortega AR et al.28	√	√	?	√	×	√	√	√	×	×	×	√	√	√
Carnes ML et al.17	√	√	×	√√	×	×	√	√	√	?	?	√	√	√
Kamisawa T et al.18	√	√	√	√	√	√	√	√	√	×	×	√	√	√
Lai R et al.19	√	√	√	√	√	√	√	√	√	×	×	√	√	√
Manfredi R et al.20	√	√	√	√	√	√	√	√	√	?	?	√	√	√
Matos C et al.21	√	√	√	√	√	√	√	√	√	×	×	√	√	√
Tandon M et al.29	√	√	√	√	×	×	√	√	×	×	×	√	√	√
Manfredi R et al.10	√	√	×	√	×	×	√	√	√	×	×	√	√	√
Bhutani MS et al.30	√	√	√	√	×	×	√	√	√	×	×	√	√	√
Ueno E et al.22	√	√	√	√	√	√	√	√	√	?	√	√	√	√
Bret PM et al.23	√	√	√	√	√	√	√	√	√	?	√	√	√	√
Soto JA et al.24	√	√	√	√	√	√	√	√	√	?	√	√	√	√

C1: Patient spectrum representative?

C2: Selection criteria described?

C3: Reference standard appropriate?

C4: Time between tests appropriate?

C5: Uniform verification by reference standard?

C6: Same reference test used?

C7: Reference standard independent?

C8: Index test described adequately?

C9: Reference standard described adequately?

C10: Blinding to reference standard results?

C11: Blinding to index test results?

C12: Appropriate clinical data available?

C13: Uninterpretable data reported?

C14: Withdrawals explained?